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That's normalising clean-ness (i.e. the state of being free of all psychoactive chemicals) perhaps too much.

The original humans adapted to a wide range of diets across the world (one reason why we're such a successful species), but most groups seem to consume mild psychoactives a lot (it's hard not to, so many wild plants have some level of activity) and seek out more powerful ones occasionally and for specific situations.

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