I cant see how people use the net without it.. My wife gets all these ad popups and she is so use to it that it doesn't even register until I point it out.
Honestly, ublock isn't even enough anymore. DNS sinkholes are the next layer, since they work device-wide. I use nextdns.io, and it's good enough that I just keep ublock around in case I need to disable nextdns for some reason.
uBlock Origin does not protect you from this, this is a fingerprinting problem. You need to use a fingerprinting resistant browser. And even then, there are new fingerprinting methods emerging frequently and you can't prevent fingerprinting from inside apps on android/iOs..
Most slop mobile applications, that many people have on their phones are basically spyware pretending to be games/whatever.
Programatic advertising technology was created for intelligence purposes, these companies and their methods are very sophisticated.
Fingerprinting is insideous because the harder you try to prevent it the more unique you become. The best method is to try to create fake data to make the fingerprint useless.