I also got sqlite-s3vfs working from Python a few months ago: https://simonwillison.net/2025/Feb/7/sqlite-s3vfs/
Both of these are very much read-only mechanisms though.
I also got sqlite-s3vfs working from Python a few months ago: https://simonwillison.net/2025/Feb/7/sqlite-s3vfs/
Both of these are very much read-only mechanisms though.