Another interesting thing: cells are packed so tightly (not just a bag of water) that proteins grind against each other and against their ligands, increasing the "activity" (even the free energy of ATP hydrolysis isn't the standard 7.3kcal/mol.
Yes, macro-scale intuition isn't great (although people pierce cell walls with tiny needles all the time), but if you spend enough time looking at cells under a microscope, you start to build an intuition about cell and molecule behavior.
Another interesting thing: cells are packed so tightly (not just a bag of water) that proteins grind against each other and against their ligands, increasing the "activity" (even the free energy of ATP hydrolysis isn't the standard 7.3kcal/mol.
Yes, macro-scale intuition isn't great (although people pierce cell walls with tiny needles all the time), but if you spend enough time looking at cells under a microscope, you start to build an intuition about cell and molecule behavior.