As an absolute fan of Blade Runner, I disliked BR2049 and I really think it was a mistake to film a sequel of the original. I don't think the original needed a sequel, the open ending and unanswered questions were perfect, and in fact most of the "tied loose ends" of the sequel kind of run contrary to the original for me. They undermine their characters and make it all some sort of silly experiment/conspiracy that simply doesn't do it for me. I dread the thought of Ridley Scott now saying he has more stories to tell... especially if they are of the "quality" of his Alien/Prometheus sequels.
I think I would have enjoyed BR2049 better had it been an entirely new movie and not a sequel to something. And if it didn't have Jared Leto overacting, of course, but I suppose that cannot be helped.
Then it shouldn't have been a sequel in the fist place.